Open AccessDesign, Synthesis and Antimicrobial Evaluations of Novel 3,7-Disubstituted 2H-1-Benzopyran-2-ones
Author(s) -
Parmesh Kumar Dwivedi,
Ashutosh Pathak,
P. Malairajan,
Devdutt Chaturvedi
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22659
Subject(s) - chemistry , antimicrobial , coumarin , benzopyran , antifungal , trichophyton , fluconazole , ring (chemistry) , ether , stereochemistry , combinatorial chemistry , organic chemistry , traditional medicine , microbiology and biotechnology , biology , medicine
In present study, a novel class of 3,7-disubstituted 2H-1-benzopyran-2-one derivatives (3xa-3zc) bearing a basic ether side chain at C-7and a substituted phenyl ring at C-3 of the coumarin ring is synthesized. These compounds have been evaluated for antimicrobial(antibacterial/antifungal) activities. Some of the compounds viz. 3xc, 3xe, 3xf, 3yb, 3yc and 3yf have shown significant antifungalactivities against selective strains. Compounds 3xe, 3yb and 3yc with the MIC values of 1.56 μg/mL displayed better antifungal activitythan fluconazole against Trichophyton mentagrophytes