Open AccessSynthesis, Characterization and Docking Studies of Anti-HCV Molecules
Author(s) -
Satish Kumar,
Priyabrata Santra,
Jaya Dwivedi,
Reza Aryan
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22618
Subject(s) - chemistry , docking (animal) , molecule , combinatorial chemistry , ns3 , stereochemistry , protease , hepatitis c virus , enzyme , biochemistry , virus , organic chemistry , virology , medicine , nursing , biology
The present study reports the synthesis and characterization of novel molecules inhibiting the spreadof hepatitis C. The molecules were designed as to block the NS3/4A protease enzyme on HCV RNA.The molecules were synthesized using usual peptide synthesis techniques. Compounds with puritymore than 95% were characterized and docking studies were also performed. All the compounds werecharacterized using physico-chemical techniques such as determination of melting point by DSC andNMR, mass, IR spectral studies. The docking studies were also conducted to assess the activity ofmolecules for inhibition of hepatitis C virus.