Open AccessDesign, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives
Author(s) -
Vijay Sharma,
Anup Barde,
Sunita Rattan
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22565
Subject(s) - chemistry , thiazolidine , knoevenagel condensation , pyrimidine , regioselectivity , combinatorial chemistry , coupling reaction , organic chemistry , stereochemistry , catalysis
Novel thiazolidine-2,4-dione (TZD) based pyrimidine derivatives have been synthesized byKnoevenagel condensation reaction between thiazolidine-2,4-dione and amino pyrimidinyl aliphaticaldehydes followed by heterogeneous metal reduction. Synthetic strategy involved nucleophillicsubstitution of hydroxyl protected six membered aliphatic chain on 4,6-dichloropyrimidine followedby Suzuki coupling. This approach is regioselective, efficient and versatile for synthesis of such analogs