Open AccessSynthesis, Spectroscopic, Thermal and in vitro Antimicrobial Activity of Fe(III) and Mn(III) Metal Complexes of Semicarbazone
Author(s) -
Chintan P. Somaiya,
Dinesh S. Patel,
Darshan H. Jani
Publication year - 2020
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22450
Subject(s) - semicarbazone , chemistry , pyrazolone , bacillus subtilis , antimicrobial , nuclear chemistry , bacillus megaterium , metal , elemental analysis , stereochemistry , organic chemistry , bacteria , biology , genetics
In this work novel pyrazolone based semicarbazone derivatives and their spectroscopic and biological activities were investigated. Pyrazolone based semicarbazone ligands and their Fe(III) and Mn(III) heterochelates were synthesized. The structure of semicarbazone ligands were confirmed by 1H NMR, IR, elemental analysis and their heterochelates were confirmed by thermal studies (TGA/DTG & DSC) and FAB mass spectroscopy. All the ligands and heterochelates were screened for antimicrobial study against Gram positive (Bacillus megaterium, Bacillus subtilis) and Gram negative (E. coli, Klebsiella) microorganisms. The results confirmed that semicarbazone based heterochelates have a great potential and significant for further investigation.