Open AccessSynthesis and Antimicrobial Activity of Some Novel 1,4-Dihydropyridine Trimer Derivatives
Author(s) -
D. Ashokkumar,
M. Gopalakrishnan,
G. Ramalingam
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22339
Subject(s) - chemistry , trimer , dihydropyridine , antimicrobial , combinatorial chemistry , melamine , microwave irradiation , acetic acid , catalysis , organic chemistry , calcium , dimer
An efficient multi-component one pot synthesis of some novel bioactive 1,4-dihydropyridine derivatives from melamine using various aldehydes and 1,3-dicarbonyl compounds are reported. This reaction carried out microwave irradiation under solvent free condition using low cost and efficient acetic acid catalyst. The excellent futures of this method are eco-friendly, short reaction time and mild reactioncondition. This method is convincing route for highly substituted dihydropyridine trimer synthesis. The synthesized dihydropyridine derivatives are screened for antimicrobial properties.