Open AccessOne Pot, Four Component Synthesis of Phthalazine-1,4-diones Derivatives in [BMIM][OH] Medium
Author(s) -
D. P. Loka Maheshwari,
B. Satyanarayana
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2020.22180
Subject(s) - chemistry , phthalazine , malononitrile , benzaldehyde , yield (engineering) , ethyl cyanoacetate , acetophenone , organic chemistry , phthalate , component (thermodynamics) , medicinal chemistry , nuclear chemistry , catalysis , materials science , physics , metallurgy , thermodynamics
[BMIM][OH] mediated, green and efficient synthesis of phthalazines (5) have been developed by condensing diethyl phthalate (1), ethyl cyanohydrazide (2), substituted benzaldehyde (3) and malononitrile (4) in the presence of Meldrum’s acid at 60-65 °C and at room temperature for 60-90 min. The importance of this method includes shorter reaction time and high yield.