Open AccessFormation Constants of Mixed Ligand Complexes of Anti-Inflammatory Drug Piroxicam and Some Bioligands with Copper(II)
Author(s) -
Amal M. AlMohaimeed
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22298
Subject(s) - chemistry , piroxicam , ligand (biochemistry) , copper , threonine , serine , tyrosine , stability constants of complexes , drug , inorganic chemistry , medicinal chemistry , receptor , biochemistry , pharmacology , organic chemistry , aqueous solution , enzyme , medicine , alternative medicine , pathology
The formation constants of various complexes of copper(II) with anti-inflammatory drug piroxicam (P) as primary ligand and some bioligands such as L-serine, L-tyrosine, L-threonine as secondary ligand have been determined pH metrically at 25 ºC and I = 0.1 M NaNO3. The results suggest that the formation of Cu(P)L and Cu(P)(LH-1) species in the pH range of 5-12. The values of Δ log10 K, percentage of relative stabilization and log X were evaluated and discussed.