Open AccessA Concise and Efficient Synthesis of an Impurity, N-Desmethyl Alcaftadine from Alcaftadine: An H1 Antagonist
Author(s) -
G. Sravya,
G. V. Zyryanov,
K. Ramaseshaiah,
Guda Mallikarjuna Reddy,
Reddy Suresh,
N. Bakthavatchala Reddy,
Г. В. Зырянов
Publication year - 2019
Publication title -
asian journal of chemistry/asian journal of chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.145
H-Index - 34
eISSN - 0975-427X
pISSN - 0970-7077
DOI - 10.14233/ajchem.2019.22059
Subject(s) - desmethyl , chemistry , yield (engineering) , antagonist , chromatography , combinatorial chemistry , metabolite , biochemistry , thermodynamics , physics , receptor
Herein, a simple approach for the synthesis of N-desmethyl alcaftadine, an H1 histamine antagonist in solid state and its structure is presented. The reactions were performed under mild and metal free conditions at reflux temperature within a range of 65-70 ºC and the desired product N-desmethyl alcaftadine was obtained in high purity with good yield (96.42 %). It was detected by ultra-high-performance liquid chromatography (UHPLC).