Open AccessFatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer
Author(s) -
Javier A. Menéndez,
Alejandro VázquezMartín,
Francisco Ortega,
José Manuel FernándezReal
Publication year - 2009
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2008.115352
Subject(s) - insulin resistance , fatty acid synthase , type 2 diabetes , diabetes mellitus , insulin , endocrinology , medicine , metabolic syndrome , bioinformatics , biology , lipid metabolism
An emerging paradigm supports the notion that deregulation of fatty acid synthase (FASN)-catalyzed de novo FA biogenesis could play a central role in the pathogenesis of metabolic diseases sharing the hallmark of insulin-resistance.
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