Open AccessUltrahigh-resolution optical coherence tomography/angiography with an economic and compact supercontinuum laser
Author(s) -
Tai-Ang Wang,
MingChe Chan,
HsiangChieh Lee,
Cheng-Yu Lee,
MengTsan Tsai
Publication year - 2019
Publication title -
biomedical optics express
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.362
H-Index - 86
ISSN - 2156-7085
DOI - 10.1364/boe.10.005687
Subject(s) - supercontinuum , optical coherence tomography , optics , laser , spectrometer , coherence (philosophical gambling strategy) , ghost imaging , laser linewidth , materials science , optical tomography , coherence length , superluminescent diode , resolution (logic) , physics , optical fiber , computer science , superconductivity , quantum mechanics , artificial intelligence , photonic crystal fiber
In this study, a Q-switch pumped supercontinuum laser (QS-SCL) is used as a light source for in vivo imaging via ultrahigh-resolution optical coherence tomography and angiography (UHR-OCT/OCTA). For this purpose, an OCT system based on a spectral-domain detection scheme is constructed, and a spectrometer with a spectral range of 635 - 875 nm is designed. The effective full-width at half maximum of spectrum covers 150 nm, and the corresponding axial and transverse resolutions are 2 and 10 µm in air, respectively. The relative intensity noise of the QS-SCL and mode-locked SCL is quantitatively compared. Furthermore, a special processing algorithm is developed to eliminate the intrinsic noise of QS-SCL. This work demonstrates that QS-SCLs can effectively reduce the cost and size of UHR-OCT/OCTA instruments, making clinical applications feasible.
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