Open AccessRetinoids Induced Cancer Stem Cell Differentiation and Apoptosis for Cancer Therapies
Author(s) -
Xin Cao
Publication year - 2019
Publication title -
journal of green engineering
Language(s) - English
Resource type - Journals
eISSN - 2245-4586
pISSN - 1904-4720
DOI - 10.13052/mct2052-8426.711
Subject(s) - cancer , cancer research , cancer stem cell , retinoid , apoptosis , cellular differentiation , stem cell , cancer cell , programmed cell death , biology , differentiation therapy , cell , melanoma , cell growth , medicine , microbiology and biotechnology , retinoic acid , cell culture , biochemistry , acute promyelocytic leukemia , genetics , gene
Retinoids show great potential in various kinds of cancer chemotherapy due to its ability to induce signals for cell differentiation or death, as well as inhibit cancer stem cell proliferation. This paper summarized the recent progress of retinoids induced cancer stem cell differentiation and apoptosis in cancer therapy field, with the highlighted novel retinoid named WYC-209 in our lab, which could inhibit the tumor stem cell and malignant melanoma tumors with high efficacy and little toxicity.