Open AccessChidamide based combination regimen for treatment of monomorphic epitheliotropic intestinal T cell lymphoma following radical operation: Two case reports
Author(s) -
Tingzhi Liu,
Yijia Zheng,
Zhanwen Zhang,
Shanshan Li,
Jiao-Ting Chen,
Aihua Peng,
Ruxun Huang
Publication year - 2020
Publication title -
world journal of clinical cases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.368
H-Index - 10
ISSN - 2307-8960
DOI - 10.12998/wjcc.v8.i7.1278
Subject(s) - medicine , regimen , lymphoma , perforation , gastroenterology , surgery , sigmoid colon , rectum , punching , materials science , metallurgy
Monomorphic epitheliotropic intestinal T cell lymphoma (MEITL) is a rare extra-nodal T-cell lymphoma that has uniformly aggressive features with a poor prognosis. No standardized treatment protocols have been established. Previous experience has demonstrated favorable outcomes with combination chemotherapy followed by autologous hematopoietic stem cell transplant. However, many patients are unable to tolerate the toxicities. Chidamide is a new histone deacetylase inhibitor that has shown preferential efficacy in mature T-cell lymphoma.