In vitro and in vivo trypanocidal action of aescin and aescin liposomes against Trypanosoma evansi in experimental mice | Zendy

Matheus D. Baldissera | Zendy; Nathieli B. Bottari | Zendy; Thirssa H. Grando | Zendy; Roberto Christ Vianna Santos | Zendy; Ana Júlia Figueiró Dalcin | Zendy; Patrícia Gomes | Zendy; Renata Platcheck Raffin | Zendy; Carine Eloise Prestes Zimmerman | Zendy; Jânio Morais Santúrio | Zendy; Sílvia González Monteiro | Zendy; Aleksandro S. Da Silva | Zendy

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In vitro and in vivo trypanocidal action of aescin and aescin liposomes against Trypanosoma evansi in experimental mice

Author(s) -

Matheus D. Baldissera,

Nathieli B. Bottari,

Thirssa H. Grando,

Roberto Christ Vianna Santos,

Ana Júlia Figueiró Dalcin,

Patrícia Gomes,

Renata Platcheck Raffin,

Carine Eloise Prestes Zimmerman,

Jânio Morais Santúrio,

Sílvia González Monteiro,

Aleksandro S. Da Silva

Publication year - 2014

Publication title -

asian pacific journal of tropical biomedicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.507

H-Index - 61

eISSN - 2588-9222

pISSN - 2221-1691

DOI - 10.12980/apjtb.4.2014apjtb-2014-0435

Subject(s) - trypanosoma evansi , in vivo , liposome , in vitro , pharmacology , trypanosoma , trypanocidal agent , biology , chemistry , trypanosomiasis , biochemistry , trypanosoma brucei , immunology , virology , microbiology and biotechnology , gene

ObjectiveTo verify the trypanocidal effectiveness of aescin and aescin liposomes against Trypanosoma evansi in vitro and in vivo.MethodsAescin and aescin liposomes were used in vitro on trypomastigotes at different concentrations (0.5%, 1.0% and 2.0%) and exposure times (0, 1, 3, 6 and 9 h). In vivo tests were performed using mice as the experimental model. Trypanosome evansi infected mice were treated with aescin and aescin liposomes with doses of 60 and 100 mg/kg during 4 d.ResultsThe three concentrations tested in free form and nanoencapsulated showed trypanocidal activity in vitro, completely eliminating the parasites in small concentration after 6 h of assay. Animals treated with aescin (100 mg/kg) and aescin liposomes (100 mg/kg) showed increase in longevity, however without curative effect.ConclusionsActive compounds present in natural products, such as aescin, may potentiate the treatment of trypanosomosis when used in association with other trypanocidal drugs

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