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Origin of malignant centrofacial granulomas: Surface markers and gene rearrangement of malignant cells
Author(s) -
Cabane J.,
Raphaël M.,
Lamas G.,
Mossalayi Djavad,
Dubois A.,
Chomette G.,
Godeau P.,
MartyDouble C.,
Rossi J. F.
Publication year - 1991
Publication title -
the laryngoscope
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.181
H-Index - 148
eISSN - 1531-4995
pISSN - 0023-852X
DOI - 10.1288/00005537-199109000-00012
Subject(s) - pathology , cd19 , biology , cd3 , lymphoma , cd20 , t cell , etiology , gene rearrangement , antigen , immunology , gene , medicine , immune system , genetics , cd8
Abstract Malignant centrofacial granuloma (MCFG) is a clinical entity characterized by a relentless ulceration of the upper airway involving the nose, palate, and face, without any demonstrable etiology. The origin of 11 cases were analyzed with the help of cell‐surface immunostaining in all and with T‐cell receptor gene (TCR) rearrangement in 3. The results show that most of the cases of MCFG are in fact T‐cell lymphomas with cell‐surface antigens (CD2, CD7, CD3) consistent with either early or mature T lymphocytes. However, some cases exhibit B‐lymphoid (CD19, CD20) or histiomonocytic (CD13, CD14) lineage‐specific markers. In conclusion, despite its remarkable clinical unity, MCFG is a heterogeneous group of neoplastic diseases, most but not all of which may be classified as T‐cell lymphoma.