Open AccessPROGESTERONE RECEPTORS: A REPRODUCTIVE ROLE
Author(s) -
И. В. Довжикова,
И. В. Довжикова,
Irina Andrievskaya,
Irina Andrievskaya,
Kseniya Petrova,
Kseniya Petrova
Publication year - 2018
Publication title -
bûlletenʹ fiziologii i patologii dyhaniâ
Language(s) - English
Resource type - Journals
ISSN - 1998-5029
DOI - 10.12737/article_5c1278d242a333.68376622
Subject(s) - receptor , myometrium , progesterone receptor , endometrium , nuclear receptor , placenta , biology , action (physics) , hormone , microbiology and biotechnology , endocrinology , medicine , pregnancy , chemistry , uterus , biochemistry , genetics , physics , gene , fetus , estrogen receptor , cancer , quantum mechanics , breast cancer , transcription factor
The article presents modern data on the mechanism of progesterone action. Genomic and non-genomic ways of hormone action realized through different types of receptors (nuclear and membrane-associated) are considered. In addition, auxiliary proteins are described; in their functioning ATP binding plays an important role. It is emphasized that the specific effects of progesterone in various tissues depend on the set of receptors and their co-regulators. A special emphasis is made on the functions of the progesterone receptors in the endometrium and myometrium. The results of the study of progesterone receptors in placenta are summarized. It was concluded that there is a necessity in the further research of progesterone receptors in complicated pregnancy with a decrease in the implementation of progesterone effects.