DIFFERENTIAL SUSCEPTIBILITY OF L CELLS IN THE EXPONENTIAL AND STATIONARY PHASES TO CADMIUM CHLORIDE | Zendy

Kazuko Ozawa | Zendy; Atsushige Sato | Zendy; Hiroaki Okada | Zendy

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DIFFERENTIAL SUSCEPTIBILITY OF L CELLS IN THE EXPONENTIAL AND STATIONARY PHASES TO CADMIUM CHLORIDE

Author(s) -

Kazuko Ozawa,

Atsushige Sato,

Hiroaki Okada

Publication year - 1976

Publication title -

the japanese journal of pharmacology

Language(s) - English

Resource type - Journals

eISSN - 1347-3506

pISSN - 0021-5198

DOI - 10.1254/jjp.26.347

Subject(s) - cadmium chloride , differential (mechanical device) , chloride , exponential function , cadmium , chemistry , mathematics , physics , mathematical analysis , thermodynamics , organic chemistry

Comparative studies of the cellular toxicity and uptake of cadmium in L cells in the exponential and stationary phases were done. The LD50 of cadmium chloride to L cells in the exponential and stationary phases was 5.5 and 30.5 muM respectively and the cadmium content of L cells exposed to 5.4 muM cadmium chloride for 3.5 hr in the exponential and stationary phases was 0.123 and 0.065 mug/10(6) cells, respectively. These results suggest that the higher susceptibility of cells in the exponential phase to cadmium may be caused by an increased permeability of the cell membrane to cadmium.

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