tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration | Zendy

Kazu Kikuchi | Zendy; Vikas Gupta | Zendy; Jinhu Wang | Zendy; Jennifer E. Holdway | Zendy; Airon A. Wills | Zendy; Yi Fang | Zendy; Kenneth D. Poss | Zendy

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tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

Author(s) -

Kazu Kikuchi,

Vikas Gupta,

Jinhu Wang,

Jennifer E. Holdway,

Airon A. Wills,

Yi Fang,

Kenneth D. Poss

Publication year - 2011

Publication title -

development

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.754

H-Index - 325

eISSN - 1477-9129

pISSN - 0950-1991

DOI - 10.1242/dev.067041

Subject(s) - biology , zebrafish , regeneration (biology) , heart development , microbiology and biotechnology , fate mapping , transcription factor , embryonic stem cell , endocardium , anatomy , gene , medicine , genetics

Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.

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