Open AccessmicroPrimer: the biogenesis and function of microRNA
Author(s) -
Tingting Du,
Phillip D. Zamore
Publication year - 2005
Publication title -
development
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.754
H-Index - 325
eISSN - 1477-9129
pISSN - 0950-1991
DOI - 10.1242/dev.02070
Subject(s) - biology , microrna , rna interference , trans acting sirna , small interfering rna , gene , small rna , argonaute , genetics , rna silencing , gene expression , rna , computational biology , biogenesis , small nucleolar rna , function (biology) , microbiology and biotechnology , non coding rna
Discovered in nematodes in 1993, microRNAs (miRNAs) are non-coding RNAs that are related to small interfering RNAs (siRNAs), the small RNAs that guide RNA interference (RNAi). miRNAs sculpt gene expression profiles during plant and animal development. In fact, miRNAs may regulate as many as one-third of human genes. miRNAs are found only in plants and animals, and in the viruses that infect them. miRNAs function very much like siRNAs, but these two types of small RNAs can be distinguished by their distinct pathways for maturation and by the logic by which they regulate gene expression.
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