Open AccessPersistent Nociception Facilitates the Extinction of Morphine-Induced Conditioned Place Preference
Author(s) -
Zerong You,
Weihua Ding,
Jason T Doheny,
Jinsheng Yang,
Liuyue Yang,
Grewo Lim,
Jiamin Miao,
Lucy Chen,
Shiqian Shen,
Jianren Mao
Publication year - 2019
Publication title -
anesthesia and analgesia/anesthesia and analgesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.404
H-Index - 201
eISSN - 1526-7598
pISSN - 0003-2999
DOI - 10.1213/ane.0000000000003819
Subject(s) - conditioned place preference , morphine , sni , nociception , medicine , opioid , anesthesia , analysis of variance , hyperalgesia , chronic pain , addiction , pharmacology , chemistry , receptor , psychiatry , biochemistry , hydrolysis , acid hydrolysis
As opioid abuse and addiction have developed into a major national health crisis, prescription of opioids for pain management has become more controversial. However, opioids do help some patients by providing pain relief and improving the quality of life. To better understand the addictive properties of opioids under chronic pain conditions, we used a conditioned place preference (CPP) paradigm to examine the rewarding properties of morphine in rats with persistent nociception.