Open AccessPlasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease
Author(s) -
Ignacio Illán-Gala,
Alberto Lleó,
Anna Karydas,
Adam M. Staffaroni,
Henrik Zetterberg,
Rajeev Sivasankaran,
Lea T. Grinberg,
Salvatore Spina,
Joel H. Kramer,
Eliana Marisa Ramos,
Giovanni Coppola,
Renaud La Joie,
Gil D. Rabinovici,
David C. Perry,
Maria Luisa GornoTempini,
William W. Seeley,
Bruce L. Miller,
Howard J. Rosen,
Kaj Blennow,
Adam L. Boxer,
Julio C. Rojas
Publication year - 2021
Publication title -
neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.91
H-Index - 364
eISSN - 1526-632X
pISSN - 0028-3878
DOI - 10.1212/wnl.0000000000011226
Subject(s) - frontotemporal lobar degeneration , pathology , biomarker , medicine , alzheimer's disease , degenerative disease , psychology , disease , frontotemporal dementia , dementia , chemistry , biochemistry
To test the hypothesis that plasma total tau (t-tau) and neurofilament light chain (NfL) concentrations may have a differential role in the study of frontotemporal lobar degeneration syndromes (FTLD-S) and clinically diagnosed Alzheimer disease syndromes (AD-S), we determined their diagnostic and prognostic value in FTLD-S and AD-S and their sensitivity to pathologic diagnoses.