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Regulation of Cancer Cell Survival by Par‐4
Author(s) -
RANGANATHAN PADHMA,
RANGNEKAR VIVEK M.
Publication year - 2005
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1339.046
Subject(s) - apoptosis , cancer , cancer research , prostate cancer , cancer cell , function (biology) , microbiology and biotechnology , cancer therapy , biology , chemistry , biochemistry , genetics
A bstract : Prostate apoptosis response‐4 (Par‐4) is a unique pro‐apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par‐4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par‐4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.