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The Sesame Seed Oil Constituent, Sesamol, Induces Growth Arrest and Apoptosis of Cancer and Cardiovascular Cells
Author(s) -
JACKLIN ALIX,
RATLEDGE COLIN,
WELHAM KEVIN,
BILKO DENNIS,
NEWTON CHRISTOPHER J.
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.068
Subject(s) - sesamol , chemistry , apoptosis , biochemistry , cytotoxicity , enzyme , sesame oil , biosynthesis , food science , pharmacology , biology , antioxidant , in vitro , horticulture , sesamum
A bstract : Sesamol is a potent inhibitor of fungal fatty acid biosynthesis. This effect is apparently due to inhibition of malic enzyme and the supply of NADPH that is required for this biosynthetic pathway. It is the ability of sesamol to reduce the synthesis of the coenzyme, NADPH, that makes it attractive for use in studying the effect of oxidants on tumor and vascular endothelial cells. By conducting preliminary studies on the effect of sesamol alone, it was clear that the compound demonstrated marked cytotoxicity. This paper describes the experiments performed.