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Induction of Apoptosis by Erucylphospho‐ N,N,N ‐trimethylammonium Is Associated with Changes in Signal Molecule Expressionand Location
Author(s) -
BERGER MARTIN R.,
TSONEVA IANA,
KONSTANTINOV SPIRO M.,
EIBL HANSJÖRG
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.054
Subject(s) - apoptosis , chemistry , molecule , signal (programming language) , biochemistry , computer science , organic chemistry , programming language
A bstract : At concentrations effecting apoptosis, the alkylphosphocholine ErPC3 induced increased expression of the Rb protein in breast cancer (MCF‐7) and leukemia (SKW‐3, AR‐230) cell lines as well as hypophosphorylation (K‐562, CMLT‐1, DOHH‐2) and fragmentation of Rb (BV‐173, SKW‐3) in leukemia cell lines. ErPC3 exerts at least part of its antineoplastic activity by apoptosis, and this chain of events comprises early changes in the lipid raft fraction of the cellular membrane as well as modulation of different signal molecules, such as Abl, Bcr‐Abl (fusion protein), and Rb.