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ICBP90 Expression Is Downregulated in Apoptosis‐Induced Jurkat Cells
Author(s) -
ABBADY ABDULQADER,
BRONNER CHRISTIAN,
TROTZIER MARIEALINE,
HOPFNER RAPHAEL,
BATHAMI KAWTAR,
MULLER CHRISTIAN D.,
JEANBLANC MICHAEL,
MOUSLI MARC
Publication year - 2003
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1299.052
Subject(s) - jurkat cells , apoptosis , downregulation and upregulation , microbiology and biotechnology , carcinogenesis , cancer cell , chemistry , biology , gene , cancer , immunology , t cell , biochemistry , genetics , immune system
A bstract : Inhibition of apoptosis, resulting from an increase in anti‐apoptotic protein, plays a fundamental role in carcinogenesis. Because ICBP90 gene expression is deregulated in cancer cells, we studied its expression in Jurkat cells under apoptotic conditions to see whether ICBP90 is involved in the regulation of apoptosis. We found that ICBP90 expression and the percentage of living cells were dose‐dependently decreased in PHA and ionophore A23187‐stimulated Jurkat cells, but not in THP‐1 cells. These results suggest that apoptosis is dependent upon ICBP90 expression downregulation and that ICBP90 exhibits anti‐apoptotic properties.