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Cirrhosis Progression as a Model of Accelerated Senescence: Affecting the Biological Aging Clock by a Breakthrough Biophysical Methodology
Author(s) -
MARINEO G,
MAROTTA F,
SISTI G
Publication year - 2004
Publication title -
annals of the new york academy of sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.712
H-Index - 248
eISSN - 1749-6632
pISSN - 0077-8923
DOI - 10.1196/annals.1297.107
Subject(s) - medicine , cirrhosis , esophageal varices , edema , portal hypertension , cardiology , ultrasound , erythema , atrophy , gastroenterology , surgery , radiology
A bstract : To test new treatment modalities, a pilot study with a novel noninvasive biophysical methodology (Delta‐S DVD) that can artificially exert a “decrease of entropy” through the patented electromagnetic‐driven delivery of “energy clusters” was designed. This process has been modulated and integrated by the body as a “self” source to support the energy‐dependent functional stores, thus modifying reparative into regenerative mechanisms of liver parenchyma. Seven long‐standing hepatitis C virus‐positive (Child A‐B) cirrhosis patients with overt symptoms and portal hypertension and failure or side effects of antiviral drug treatment underwent 40‐min sessions of Delta‐S DVD daily for six months and were followed up monthly. At the end of the first month, rapid improvement of symptoms and a decrease of portal hypertension were noted. At the end of treatment, all patients showed either a complete (80%) or a partial (20%) regression of fatigue (FISK score), peripheral edema, pruritus, and palmar erythema. As observed, despite having stopped beta‐blockers, F1 esophageal varices disappeared (60%), whereas F2 decreased to F1. The Doppler ultrasound aspect of partial (40%) or total (20%) atrophy was either reduced (60%) or reverted to normal (20%), and the respiratory dynamics of the portal vein improved (80%) or normalized (20%), whereas gross scarring nodules disappeared in 40% of cases. These promising data pave the way for an innovative physiopathological approach with extensive clinical applications.