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Role of CXCR4‐mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia
Author(s) -
Jost Tanja Rezzonico,
Borga Chiara,
Radaelli Enrico,
Romagnani Andrea,
Perruzza Lisa,
Omodho Lorna,
Cazzaniga Giovanni,
Biondi Andrea,
Indraccolo Stefano,
Thelen Marcus,
Kronnie Geertruy,
Grassi Fabio
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5ma0915-394r
Subject(s) - cxc chemokine receptors , biology , bone marrow , cancer research , leukemia , immunology , chemokine receptor , pathology , medicine , chemokine , inflammation
CXCR4 in T‐ALL cells promotes BM colonization, a prelude to meninges invasion and potential pharmacological target for this leukemia.