Premium
A neutralizing anti–G‐CSFR antibody blocks G‐CSF–induced neutrophilia without inducing neutropenia in nonhuman primates
Author(s) -
ScalzoInguanti Karen,
Monaghan Katherine,
Edwards Kirsten,
Herzog Eva,
Mirosa Danijela,
Hardy Matthew,
Sorto Vicki,
Huynh Huy,
Rakar Steven,
Kurtov Daria,
Braley Hal,
Wilson Nick,
Busfield Samantha,
Nash Andrew,
Andrews Arna
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5a1116-489r
Subject(s) - neutrophilia , neutropenia , immunology , inflammation , leukopenia , granulocyte colony stimulating factor , antibody , absolute neutrophil count , biology , granulocyte , medicine , pharmacology , chemotherapy
Antibody blockade of NHP G‐CSFR in vivo blocks STAT signaling without impacting peripheral neutrophil numbers or basic neutrophil functions.