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The protease inhibitor cystatin C down‐regulates the release of IL‐β and TNF‐α in lipopolysaccharide activated monocytes
Author(s) -
Gren Susanne Thiesen,
Janciauskiene Sabina,
Sandeep Salipalli,
Jonigk Danny,
Kvist Peter Helding,
Gerwien Jens Gammeltoft,
Håkansson Katarina,
Grip Olof
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5a0415-174r
Subject(s) - tumor necrosis factor alpha , biology , proinflammatory cytokine , monocyte , chemokine , immunology , cytokine , inflammation
CysC is taken up by monocytes, and when exposed to bacterial antigen, respond with a dampened release of pro‐inflammatory cytokines.