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Rac1‐dependent secretion of platelet‐derived CCL5 regulates neutrophil recruitment via activation of alveolar macrophages in septic lung injury
Author(s) -
Hwaiz Rundk,
Rahman Milladur,
Syk Ingvar,
Zhang Enming,
Thorlacius Henrik
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a1214-603r
Subject(s) - ccl5 , cxcl2 , cxcl1 , chemokine , immunology , chemotaxis , lung , cancer research , biology , inflammation , receptor , medicine , immune system , chemokine receptor , t cell , biochemistry , il 2 receptor
Rac1 regulates platelet secretion of CCL5, where CCL5 is a potent inducer of neutrophil recruitment in septic lung injury via formation of CXCL2 in alveolar macrophages.