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JAK/STAT regulation of Aspergillus fumigatus corneal infections and IL‐6/23‐stimulated neutrophil, IL‐17, elastase, and MMP9 activity
Author(s) -
Taylor Patricia R.,
Roy Sanhita,
Meszaros Evan C.,
Sun Yan,
Howell Scott J.,
Malemud Charles J.,
Pearlman Eric
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a1015-483r
Subject(s) - biology , aspergillus fumigatus , neutrophil elastase , elastase , jak stat signaling pathway , immunology , receptor , inflammation , biochemistry , tyrosine kinase , enzyme
Ruxolitinib blockade of STAT3 phosphorylation in IL‐6/23‐ stimulated neutrophils, inhibits RORγt translocation, IL‐1‐ induced production of ROS, MMP9, and elastase activity, and modulates Aspergillus fumigatus corneal infections.