Premium
Absence of CCR2 results in an inflammaging environment in young mice with age‐independent impairments in muscle regeneration
Author(s) -
Melton David W.,
Roberts Alexander C.,
Wang Hanzhou,
Sarwar Zaheer,
Wetzel Michael D.,
Wells Jason T.,
Porter Laurel,
Berton Michael T.,
McManus Linda M.,
Shireman Paula K.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3ma0316-104r
Subject(s) - biology , regeneration (biology) , microbiology and biotechnology , senescence , endocrinology
CCR2 KO has impaired myeloid recruitment, regeneration, and failure of regenerated myofibers to attain baseline size despite increased tissue cytokines/chemokines.