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Sphingosine‐1‐phosphate induces thrombin receptor PAR‐4 expression to enhance cell migration and COX‐2 formation in human monocytes
Author(s) -
MahajanThakur Shailaja,
Sostmann Björn D.,
Fender Anke C.,
Behrendt Daniel,
Felix Stephan B.,
Schrör Karsten,
Rauch Bernhard H.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3ab1013-567r
Subject(s) - thrombin , monocyte , sphingosine 1 phosphate , biology , microbiology and biotechnology , thrombin receptor , chemotaxis , mapk/erk pathway , tissue factor , receptor , signal transduction , immunology , coagulation , medicine , biochemistry , sphingosine , platelet
S1P induces expression of the protease‐activated receptor‐4 (PAR‐4) in human monocytes, and enhances chemotaxis and COX‐2 formation in response to thrombin.