Premium
Expression and role of a2 vacuolar‐ATPase (a2V) in trafficking of human neutrophil granules and exocytosis
Author(s) -
GilmanSachs Alice,
Tikoo Anjali,
AkmanAnderson Leyla,
Jaiswal Mukesh,
Ntrivalas Evangelos,
Beaman Kenneth
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a1214-620rr
Subject(s) - exocytosis , granule (geology) , intracellular , cytosol , chemistry , microbiology and biotechnology , biochemistry , secretion , biophysics , biology , enzyme , paleontology
The a2 isoform of V‐ATPase on neutrophil granule membranes decreases intragranular pH as the cytoplasmic pH becomes acidic after stimulation, facilitates exocytosis, and translocates to the cell surface.