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IFNAR signaling directly modulates T lymphocyte activity, resulting in milder experimental autoimmune encephalomyelitis development
Author(s) -
Kavrochorianou Nadia,
Evangelidou Maria,
Markogiannaki Melina,
Tovey Michael,
Thyphronitis George,
Haralambous Sylva
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a1214-598r
Subject(s) - experimental autoimmune encephalomyelitis , multiple sclerosis , biology , interferon , immunology , encephalomyelitis , autoimmunity , transgene , autoimmune disease , t cell , interferon gamma , cytokine , immune system , antibody , biochemistry , gene
A T cell‐associated protective effect of IFNAR activation is revealed using a novel transgenic mouse model with functional IFNAR expression.