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Down‐regulation of survivin alleviates experimental arthritis
Author(s) -
Andersson K. M. E.,
Svensson M. N. D.,
Erlandsson M. C.,
Jonsson IM.,
Bokarewa M. I.
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0714-317r
Subject(s) - survivin , cancer research , inflammation , arthritis , small hairpin rna , biology , apoptosis , immunology , foxp3 , immune system , gene knockdown , biochemistry
Inhibiting survivin is sufficient to reduce joint inflammation and bone damage in arthritis by a p53‐independent control of lymphocyte proliferation.