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Ligand‐dependent serum response factor activation by the human CC chemokine receptors CCR2a and CCR2b is mediated by G proteins of the G q family
Author(s) -
Vatter Petra,
Schuhholz Julia,
Koenig Carolin,
Pfreimer Mariana,
Moepps Barbara
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2ma0815-386r
Subject(s) - gtpase , biology , guanine nucleotide exchange factor , gq alpha subunit , microbiology and biotechnology , g protein , heterotrimeric g protein , signal transduction , chemokine receptor , receptor , transcription factor , pertussis toxin , chemokine , biochemistry , gene
Gα q and/or Gα 14 in CCR2a/CCR2b‐stimulated RhoA‐GTPase‐mediated SRF activation, and introduce a non‐canonical pathway activated by CCR2 receptors by coupling to G q proteins.