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IL‐18‐dependent NKG2D ligand upregulation on accessory cells is mediated by the PI3K/GSK‐3 pathway
Author(s) -
Brandstadter Joshua D.,
Chen Huiyao,
Jiang Songfu,
Huang Xiaopei,
Yang Yiping
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0816-342r
Subject(s) - downregulation and upregulation , nkg2d , pi3k/akt/mtor pathway , microbiology and biotechnology , biology , regulator , signal transduction , t cell , immunology , in vitro , immune system , cytotoxic t cell , biochemistry , gene
IL18‐dependent Rae‐1 upregulation on accessory cells is mediated by the MyD88‐PI3K‐GSK3 pathway, providing important insights into the design of effective NK cell‐based immunotherapies.