Open AccessNrf2‐interacting nutrients and COVID‐19: time for research to develop adaptation strategies
Author(s) -
Bousquet Jean,
Cristol JeanPaul,
Czarlewski Wienczyslawa,
Anto Josep M.,
Martineau Adrian,
Haahtela Tari,
Fonseca Susana C.,
Iaccarino Guido,
Blain Hubert,
Fiocchi Alessandro,
Caica G. Walter,
Fonseca Joao A.,
Vidal Alain,
Choi HakJong,
Kim Hyun Ju,
Le Moing Vincent,
Reynes Jacques,
Sheikh Aziz,
Akdis Cezmi A.,
Zuberbier Torsten,
Abdul Latiff Amir Hamzah,
Abdullah Baharudin,
Aberer Werner,
Abusada Nancy,
Adcock Ian,
Afani Alejandro,
Agache Ioana,
Aggelidis Xenofon,
Agustin Jenifer,
Akdis Cezmi A,
Akdis Mübeccel,
AlAhmad Mona,
AlZahab Bassam Abou,
Alburdan Hussam,
AldreyPalacios Oscar,
Alvarez Cuesta Emilio,
Alwan Salman Hiba,
Alzaabi Ashraf,
Amade Salma,
Ambrocio Gene,
Angles Rosana,
AnnesiMaesano Isabella,
Ansotegui Ignacio J,
Anto Josep M.,
Ara Bardajo Paula,
Arasi Stefania,
Arrais Margarete,
Arshad Hasan,
Artesani MariaCristina,
Asayag Estrella,
Avolio Francesca,
Azhari Khuzama,
Bachert Claus,
Bagnasco Diego,
Baiardini Ilaria,
Bajrović Nissera,
Bakakos Petros,
Bakeyala Mongono Sergio,
BalotroTorres Christine,
Barba Sergio,
Barbara Cristina,
Barbosa Elsa,
Barreto Bruno,
Bartra Joan,
Basagana Xavier,
Bateman Eric D.,
Battur Lkhagvaa,
Bedbrook Anna,
Bedolla Barajas Martín,
Beghé Bianca,
Bekere Antra,
Bel Elizabeth,
Ben Kheder Ali,
Benson Mikael,
Berghea ElenaCamelia,
Bergmann KarlChristian,
Bernardini Roberto,
Bernstein David,
Bewick Mike,
Bialek Slawomir,
Białoszewski Artur,
Bieber Thomas,
Billo Nils E.,
Bilo MariaBeatrice,
BindslevJensen Carsten,
Bjermer Leif,
Blain Hubert,
Bobolea Irina,
Bochenska Marciniak Malgorzata,
Bond Christine,
Boner Attilio,
Bonini Matteo,
Bonini Sergio,
BosnicAnticevich Sinthia,
Bosse Isabelle,
Botskariova Sofia,
Bouchard Jacques,
Boulet LouisPhilippe,
Bourret Rodolphe,
Bousquet Philippe,
Braido Fulvio,
Briggs Andrew,
Brightling Christopher E,
Brozek Jan,
Brussino Luisa,
Buhl Roland,
Bumbacea Roxana,
Buquicchio Rosalva,
Burguete Cabañas MaríaTeresa,
Bush Andrew,
Busse William W,
Buters Jeroen,
CaballeroFonseca Fernan,
Calderon Moïses A,
Calvo Mario,
Camargos Paulo,
Camuzat Thierry,
Canevari FR,
Cano Antonio,
Caica G. Walter,
CaprilesHulett Arnaldo,
Caraballo Luis,
Cardona Vicky,
Carlsen KaiHakon,
Carmona Pirez Jonas,
Caro Jorge,
Carr Warner,
CarreiroMartins Pedro,
CarreonAsuncion Fredelita,
Carriazo AnaMaria,
Carrion y Ribas Carme,
Casale Thomas,
Castor MaryAnn,
Castro Elizabeth,
Caviglia A. G.,
Cecchi Lorenzo,
Cepeda Sarabia Alfonso,
Chalubinski Maciej,
Chandrasekharan Ramanathan,
Chang YoonSeok,
ChatoAndeza Victoria,
Chatzi Lida,
Chatzidaki Christina,
Chavannes Niels H.,
Chaves Loureiro Claudia,
Chavez Garcia AuroraAlejandra,
Chelninska Marta,
Chen Yuzhi,
Cheng Lei,
Chinthrajah Sharon,
Chivato Tomas,
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Christoff George,
Chrystyn Henry,
Chu Derek K,
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Chung Kian Fan,
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Ciprandi Giorgio,
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Compalati Enrico,
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De Feo Giulia,
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De la Torre Navarrete JoséRicardo,
De los Santos Chato,
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Didier Alain,
Dimic Janjic Sanja,
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DinhXuan Anh Tuan,
Djukanovic Ratko,
Do Ceu Texeira Maria,
Dokic Dejan,
Domínguez Silva Margarita Gabriela,
Douagui Habib,
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Doulaptsi Maria,
Dray Gérard,
Dubakiene Ruta,
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Gayraud Jacques,
Gelardi Matteo,
Gemicioglu Bilun,
Gennimata Dimitra,
Genova Sonya,
Gereda José,
Gerth van Wijk Roy,
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González Diaz Sandra,
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Guidacci Marta,
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Harvey Richard,
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HellquistDahl Birthe,
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Ibrahim Moustafa,
Ilitaliya,
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Joos Guy,
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Lalek Nika,
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Miculinic Neven,
Midão Luís,
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Stamataki Sofia,
Stefanaki Lina,
Stellato Cristiana,
Stelmach Rafael,
Strandberg Timo,
Stute Petra,
Subramaniam Abirami,
Suppli Ulrik Charlotte,
Sutherland Michael,
Sylvestre Silvia,
Syrigou Aikaterini,
Taborda Barata Luis,
Takovska Nadejda,
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Valovirta Erkka,
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Vandenplas Olivier,
Vasankari Tuula,
Vassileva Dafina,
Velasco Munoz Cesar,
Ventura Maria Teresa,
VeraMunoz Cécilia,
Viart Frédéric,
Vicheva Dilyana,
Vichyad Pakit,
Vidgren Petra,
Viegi Giovanni,
Vogelmeier Claus,
Von Hertzen Leena,
Vontetsianos Theodoros,
Vourdas Dimitris,
Tran Thien Quan Vu,
Wagenmann Martin,
Walker Samantha,
Wallace Dana,
De Wang Yun,
Waserman Susan,
Wehner Katrin,
Wickman Magnus,
Williams Sian,
Williams Dennis,
Wilson Nicola,
Wong Gary,
Woo Kent,
Wozniak Lucyna,
Wright John,
Wroczynski Piotr,
Xepapadaki Paraskevi,
Yakovliev Plamen,
Yamaguchi Masao,
Yan Kwok,
Yap Yoke Yeow,
Yassin Mais,
Yawn Barbara,
Yiallouros Panayiotis,
Yorgancioglu Arzu,
Yoshihara Shigemi,
Young Ian,
Yusuf Osman B,
Zaidi Asghar,
Zaitoun Fares,
Zalud Petra,
Zar Heather,
Zedda M. T.,
Zernotti Mario E,
Zhang Luo,
Zhong Nanshan,
Zidarn Mihaela,
Zuberbier Torsten,
Zubrinich Celia
Publication year - 2020
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/s13601-020-00362-7
Subject(s) - cytokine storm , insulin resistance , medicine , transcription factor , pi3k/akt/mtor pathway , microbiology and biotechnology , signal transduction , biology , obesity , biochemistry , covid-19 , infectious disease (medical specialty) , gene , disease
Abstract There are large between‐ and within‐country variations in COVID‐19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid‐derived 2)‐like 2) anti‐oxidant transcription factor. There are many Nrf2‐interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator‐activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal‐regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID‐19, acting through the endoplasmic reticulum stress or ACE‐Angiotensin‐II‐AT 1 R axis (AT 1 R) pathway. Many Nrf2‐interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID‐19 mortality are those with the lowest prevalence of obesity (Sub‐Saharan Africa and Asia). It is tempting to propose that Nrf2‐interacting foods and nutrients can re‐balance insulin resistance and have a significant effect on COVID‐19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID‐19 severity.