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Objective  Differential alterations in gut microbiota and chronic low-grade inflammation play a critical role in the development of Type 2 diabetes (T2D). Here we aimed to investigate if dysbiosis of inflammation and anti-inflammation-associated gut bacterial communities in fecal samples of individuals had any influence on T2D using a 16S rRNA gene of V3 region sequencing at Illumina MiSeq platform.    Results  Our findings showed that a higher abundance of inflammatory bacteria such as  Lactobacillus ruminis, Ruminococcus gnavus, Bacteroides caccae, Butyricimonas,  and  Collinsella aerofaciens , and lower abundance of anti-inflammatory bacteria such as  Faecalibacterium prausnitzii , and  Butyrivibrio  that likely play a role in the development of T2D. Our findings hint the potential of indigenous microbiota in developing diagnostic markers and therapeutic targets in T2D.

Could dysbiosis of inflammatory and anti-inflammatory gut bacteria have an implications in the development of type 2 diabetes? A pilot investigation