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Background  Dysregulated gut microbiota is one of major pathogenic factors in the development of colitis. Dock2 acts as a guanine nucleotide exchange factor (GEF) and activates small G protein RAC1. Our previous study showed that, compared to wild type (WT) mice,  Dock2   −/−   mice were more susceptible to colitis induced by  Citrobacter rodentium  infection. However, it is not clear whether gut microbiota affects the host susceptibility to enteric bacterial infection in  Dock2   −/−   mice.    Results  In this study, we demonstrated that Dock2 regulated the gut microbiota and affected the host susceptibility to  C. rodentium  infection by co-housing, fecal microbiota transfer and antibiotic treatment methods. Microbiota analysis by 16 S rRNA gene sequencing showed that Dock2 increased the abundance of  prevotellaceae-NK3B31-group  and  Lactobacillus  but decreased that of  Helicobacter .    Conclusions  These results suggest that Dock2 regulates the composition of gut microbiota and affects the host susceptibility to  C. rodentium  infection.    Supplementary Information  The online version contains supplementary material available at 10.1186/s13099-021-00449-x.

Dock2 affects the host susceptibility to Citrobacter rodentium infection through regulating gut microbiota