Open AccessIntracutaneous injection of autologous serum with specific IgE against penicillin followed by intracutaneous test with penicillin, does not elicit a positive intracutaneous test
Author(s) -
Tannert Line Kring,
Moertz Charlotte Gotthard,
Falkencrone Sidsel,
Skov Per Stahl,
BindslevJensen Carsten
Publication year - 2015
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-5-s1-o10
Subject(s) - penicillin , medicine , histamine , immunoglobulin e , saline , immunology , allergy , pharmacology , anesthesia , microbiology and biotechnology , antibiotics , antibody , biology
Background In patients allergic to penicillin only a minority of those who have specific IgE against penicillin also have a positive intracutaneous test (ICT) to penicillin and vice versa. This is in contrast to findings in patients with allergy to classical type 1 allergens, e.g. grass or peanuts. Besides that, our investigations indicates that histamine is only released in the minority of positive intracutaneous tests. The reason for this is not known. A hypothesis could be that the specific IgE against penicillin measured in serum is not present in the skin. The aim of this project is to investigate, if you by priming the skin with autologous serum in patients with specific IgE to penicillin subsequently are able to develop a positive ICT upon testing.