Open AccessGene profiling of B lymphoblastoid cell lines from DRESS patients after drugs incubation
Author(s) -
Calbo Sébastien,
Camous Xavier,
Janela Baptiste,
Périchon Kim,
Chen Jinmiao,
Chua Edmond,
Lum Josephine,
Zolezzi Francesca,
Poidinger Michael,
Musette Philippe
Publication year - 2014
Publication title -
clinical and translational allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.979
H-Index - 37
ISSN - 2045-7022
DOI - 10.1186/2045-7022-4-s3-p123
Subject(s) - immune system , medicine , immunology , cd8 , cytotoxic t cell , lymphoblast , cell culture , in vitro , biology , biochemistry , genetics
Background Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe drug-induced cutaneous reaction with visceral involvement and blood abnormalities associated with reactivations of herpes-virus family i.e., EBV, HHV-6, HHV-7 and CMV. Recently, we demonstrated that the immune response in DRESS, previously thought to be directed only against drug components, is also mediated by herpes-virus specific cytotoxic CD8+ T lymphocytes which home to the skin and visceral organs.