Open AccessThe implications of neutrophil extracellular traps in the pathophysiology of atherosclerosis and atherothrombosis
Author(s) -
Mostafa Nasr Mostafa,
Mahmoud Osama
Publication year - 2020
Publication title -
experimental biology and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 146
eISSN - 1535-3702
pISSN - 1535-3699
DOI - 10.1177/1535370220945989
Subject(s) - neutrophil extracellular traps , extracellular , inflammation , proteases , immunology , pathophysiology , pathogenesis , extracellular matrix , microbiology and biotechnology , biology , medicine , pathology , biochemistry , enzyme
Fatal consequences of atherosclerosis and atherothrombosis give research in this field great importance. This review provides recent information about the implications of neutrophils in the pathophysiology of atherosclerosis and atherothrombosis via formation and release of neutrophil extracellular traps (NETs), thereby enhancing our understanding on how the process of atherosclerosis develops and how its consequences occur. Information provided in this review suggests NETs as a new therapeutic target and a rich point for research. This review gives answers to questions about the mechanisms of atherosclerosis and atherothrombosis progression through studying the implications of NETs in these processes.