Open AccessCharacterization and significance of ACE2 and Mas receptor in human colon adenocarcinoma
Author(s) -
Stella Bernardi,
Cristina Zennaro,
Silvia Palmisano,
Elena Velkoska,
Nicoletta Sabato,
Barbara Toffoli,
Greta Giacomel,
L. Buri,
Fabrizio Zanconati,
Giuseppe Bellini,
Louise M. Burrell,
Nicolò de Manzini,
Bruno Fabris
Publication year - 2011
Publication title -
jraas. journal of the renin-angiotensin-aldosterone system/journal of the renin-angiotensin-aldosterone system
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.457
H-Index - 46
eISSN - 1752-8976
pISSN - 1470-3203
DOI - 10.1177/1470320311426023
Subject(s) - adenocarcinoma , downregulation and upregulation , angiotensin converting enzyme 2 , colorectal cancer , cancer research , renin–angiotensin system , receptor , medicine , chemistry , cancer , gene , biochemistry , disease , covid-19 , blood pressure , infectious disease (medical specialty)
A new arm of the renin-angiotensin system (RAS) has been recently characterized; this includes angiotensin converting enzyme (ACE)2 and angiotensin (Ang)1-7, a heptapeptide acting through the Mas receptor (MasR). Recent studies show that Ang1-7 has an antiproliferative action on lung adenocarcinoma cells. The aim of this study was to characterize RAS expression in human colon adenocarcinoma and to investigate whether Ang1-7 exerts an antiproliferative effect on human colon adenocarcinoma cells.