Open AccessEvaluation of [18F]-JNJ-64326067-AAA tau PET tracer in humans
Author(s) -
Suzanne L. Baker,
Karine Provost,
Wesley P. Thomas,
Ash Whitman,
Mustafa Janabi,
Mark E. Schmidt,
Maarten Timmers,
Hartmuth C. Kolb,
Gil D. Rabinovici,
William J. Jagust
Publication year - 2021
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1177/0271678x211031035
Subject(s) - positron emission tomography , tracer , nuclear medicine , physics , medicine , nuclear physics
The [ 18 F]-JNJ-64326067-AAA ([ 18 F]-JNJ-067) tau tracer was evaluated in healthy older controls (HCs), mild cognitive impairment (MCI), Alzheimer's disease (AD), and progressive supranuclear palsy (PSP) participants. Seventeen subjects (4 HCs, 5 MCIs, 5 ADs, and 3 PSPs) received a [ 11 C]-PIB amyloid PET scan, and a tau [ 18 F]-JNJ-067 PET scan 0-90 minutes post-injection. Only MCIs and ADs were amyloid positive. The simplified reference tissue model, Logan graphical analysis distribution volume ratio, and SUVR were evaluated for quantification. The [ 18 F]-JNJ-067 tau signal relative to the reference region continued to increase to 90 min, indicating the tracer had not reached steady state. There was no significant difference in any bilateral ROIs for MCIs or PSPs relative to HCs; AD participants showed elevated tracer relative to controls in most cortical ROIs (P < 0.05). Only AD participants showed elevated retention in the entorhinal cortex. There was off-target signal in the putamen, pallidum, thalamus, midbrain, superior cerebellar gray, and white matter. [ 18 F]-JNJ-067 significantly correlated (p < 0.05) with Mini-Mental State Exam in entorhinal cortex and temporal meta regions. There is clear binding of [ 18 F]-JNJ-067 in AD participants. Lack of binding in HCs, MCIs and PSPs suggests [ 18 F]-JNJ-067 may not bind to low levels of AD-related tau or 4 R tau.