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Chromium Content of Total Parenteral Nutrition Solutions
Author(s) -
Ito Yasushi,
Alcock Nancy W.,
Shils Maurice E.
Publication year - 1990
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607190014006610
Subject(s) - parenteral nutrition , enteral administration , chemistry , chromium , phosphate , atomic absorption spectroscopy , chromatography , medicine , biochemistry , organic chemistry , physics , quantum mechanics
Chromium (Cr) present as contaminant was analyzed by flameless atomic absorption spectrometry in a variety of commercially produced solutions and additives commonly used in total parenteral nutrition (TPN) formulas. Total Cr likely to be administered unintentionally per day was estimated both by summing the Cr in appropriate volumes of each solution required for preparation of standard TPN formulas and by analyzing complete TPN solutions. Storage of TPN solutions in plastic bags for 14 days did not affect Cr concentrations. The amounts ranged from 2.4 to 8.1 μg/day for a high glucose formula and 2.6 to 10.5 μg for a high lipid formula. Amino acid solutions, especially when containing phosphate, or with phosphate salt additives and with lipid emulsions accounted for approximately 85 to 90% of the Cr found. (Journal of Parenteral and Enteral Nutrition 14 :610–614, 1990)