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Influence of Total Parenteral Nutrition on Plasma Fibronectin in Malnourished Subjects with or without Inflammatory Response
Author(s) -
Sandstedt Stefan,
Cederblad Gitten,
Larsson Jörgen,
Schildt Bo,
Symreng Tommy
Publication year - 1984
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607184008005493
Subject(s) - parenteral nutrition , anorexia nervosa , orosomucoid , medicine , enteral administration , fibronectin , malnutrition , albumin , gastroenterology , anorexia , haptoglobin , transferrin , glycoprotein , biology , eating disorders , biochemistry , psychiatry , extracellular matrix
Plasma fibronectin, which is an α 2 ‐glycoprotein of importance for the immunodefence, has been reported to decrease after starvation and in severely ill patients with cancer. To evaluate the usefulness of fibronectin as an indicator of nutritional repletion, 18 patients with gastrointestinal disorders were studied over a 2‐wk period of total parenteral nutrition (TPN). According to nutritional assessment on admission the patients were divided into well nourished (n = 6) and malnourished (n = 12). For comparison nine patients with anorexia nervosa were also studied over a 3‐wk period of TPN. Before and after TPN fibronectin, albumin, prealbumin, transferrin, and two acute‐phase reactants, haptoglobin and orosomucoid were measured in plasma. The majority of the malnourished patients had an inflammatory reaction in contrast to only a few of the well‐nourished and anorexia nervosa patients. Of the proteins measured, only fibronectin rose significantly in the malnourished patients (malnourished and anorexia nervosa), but not in the well nourished patients during TPN. Our results may indicate the usefulness of fibronectin as an indicator of short‐term TPN in malnourished subjects, irrespective of the presence or absence of inflammatory response. (Journal of Parenteral and Enteral Nutrition 8:000–000, 1984)