Premium
Intravenous Protein‐sparing Therapy in Patients with Gastrointestinal Disease
Author(s) -
Greenberg Gordon R.,
Jeejeebhoy Khursheed N.
Publication year - 1979
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860717900300605
Subject(s) - ketone bodies , valine , phenylalanine , leucine , glucagon , isoleucine , medicine , amino acid , endocrinology , chemistry , nitrogen balance , alanine , glutamine , arginine , insulin , metabolism , biochemistry , nitrogen , organic chemistry
Two groups (each of 6 moderately ill, protein‐depleted patients) were infused daily for 7 days. Mean 7 day nitrogen (N) balances with infusions of 0.83 and 1.83 g of a defined amino acid mixture (containing further nutrients but no other source of energy)/kg ideal body wt/day were −3.66 and +1.54 g/day, respectively (P < 0.025) when adjusted for changes in body urea and estimated miscellaneous N losses. Concentrations of plasma free fatty acids, immunoreactive insulin and glucagon, and of blood glucose, pyruvate, lactate and glycerol were indistinguishable on corresponding treatment days in the 2 groups but blood ketone bodies were lower in the 1.83 g/kg group. Blood amino acid concentrations of alanine, valine, leucine, and isoleucine were similar, whereas those of phenylalanine, histidine, serine, and arginine were higher, and glutamine lower, in the 1.83 g/kg group. The data confirm that not only can body protein mass be maintained, but a net positive N retention achieved, in such patients, through provision of exogenous amino acids and concurrent mobilization of endogenous energy stores. Of note is that this fat mobilization can occur without plasma free fatty acids and/or significant blood ketone body elevations. An infusion of 2, rather than 1 g/kg/day seems suitable in the situation examined.