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Selenium and Total Parenteral Nutrition
Author(s) -
van Rij Andre M.,
Mc Kenzie Joan M.,
Robinson Marion F.,
Thomson Christine D.
Publication year - 1979
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860717900300406
Subject(s) - parenteral nutrition , selenium , medicine , intensive care medicine , chemistry , organic chemistry
Despite the increasing recognition of selenium (Se) as an essential trace element in man, little is known about its metabolism during total parenteral nutrition (TPN) and the possible development of Se deficiency in high risk patients. From a general population known by its geographical location to have low Se blood levels, we studied a group of 23 surgical patients receiving TPN for at least one week. Whole blood Se levels were less than in the normal general population and, being some of the lowest observed in adult man, approached levels observed in animals with Se‐responsive syndromes. Se continued to be lost predominantly in the urine although the Se content of the TPN fluids was very low (<0.6 μg/24 hr). Patients with excessive volumes of gastrointestinal excretion lost more Se. Se supplementation may be required in some patients receiving TPN.