Hyaluronan, TSG-6, and Inter-α-Inhibitor in Periprosthetic Breast Capsules: Reduced Levels of Free Hyaluronan and TSG-6 Expression in Contracted Capsules | Zendy

Kian T. Tan | Zendy; A.D. Baildam | Zendy; Ali Juma | Zendy; Caroline M. Milner | Zendy; Anthony J. Day | Zendy; Ardeshir Bayat | Zendy

Open Access

Hyaluronan, TSG-6, and Inter-α-Inhibitor in Periprosthetic Breast Capsules: Reduced Levels of Free Hyaluronan and TSG-6 Expression in Contracted Capsules

Author(s) -

Kian T. Tan,

A.D. Baildam,

Ali Juma,

Caroline M. Milner,

Anthony J. Day,

Ardeshir Bayat

Publication year - 2011

Publication title -

aesthetic surgery journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.528

H-Index - 58

eISSN - 1527-330X

pISSN - 1090-820X

DOI - 10.1177/1090820x10391778

Subject(s) - periprosthetic , capsular contracture , medicine , context (archaeology) , staining , real time polymerase chain reaction , gene expression , dupuytren's contracture , pathology , contracture , breast cancer , gene , surgery , chemistry , biology , biochemistry , cancer , paleontology , arthroplasty , breast reconstruction

The exact mechanism of capsular contracture (CC) is still unknown. The covalent modification of hyaluronan (HA) with the heavy chains (HC) of inter-α-inhibitor (IαI) has been identified as an important pathway in inflammation and tissue remodeling, where HC·HA formation is catalyzed by TSG-6 (the protein product of tumor necrosis factor stimulated gene-6).

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